英语翻译Poly-(1,6)-β-D-glucopyranosyl-(1,3)- β-D-glucopyranose (

英语翻译
Poly-(1,6)-β-D-glucopyranosyl-(1,3)- β-D-glucopyranose (PGG) β-glucan is a soluble yeast-derived polysaccharide that haspreviously been shown to induce hematopoietic progenitor cell (HPC) mobilization.However,the mobilizing mechanism of action remains unknown.Here,we confirmed that PGG β-glucan alone or in combination with granulocyte colony-stimulating factor (G-CSF) mobilizes HPC into the periphery.Optimal mobilizing effects were seen 24–48 hours after PGGβ-glucan doses of 4.8–9.6 mg/kg.Animals treated with G-CSF and PGGβ-glucan showed a collabo-rative effect in HPC mobilization compared with G-CSF treatment alone.Additional studies demonstrated that neither complement 3 nor complement receptor 3 played a role in this effect and that PGGβ-glucan treatment did not induce proinflammatory cytokine secretion.However,bone marrow cells from PGGβ-glucan-treated mice secreted abundant matrix metalloproteinase-9 (MMP-9),and PGGβ-glucan-induced HPC mobilization was abrogated in MMP-9 knockout mice.Moreover,we demonstrated that both hematopoietic and nonhematopoietic cells contributed to MMP-9 secretion upon PGGβ-glucan treatment.In addition,HPCs mobilized by PGGβ-glucan had similar levels of engraftment in host and lineage differentiation capability compared with those mobilized by G-CSF.Thus,PGG -glucan is an agent that enhances HPC mobilization and may improve the outcome of clinical stem cell transplantation.
软件翻译的明显很多地方词不达意，效果好一点。

聚（1,6）-β-D -葡糖基（ 1,3）-β-D-葡萄糖（P G G）β-葡聚糖是一种可溶性酵母源性多糖已被证明具有诱导造血祖细胞（HPC）活化的作用.然而,该活化的作用机制仍然尚未可知.我们证实了PGGβ-葡聚糖单独或联合粒细胞集落刺激因子（ G-CSF）活化造血祖细胞进入外围.每公斤体重给予4.8～9.6mg PGGβ-葡聚糖后,24～48小时之内可观测到最佳的活化效果.动物试验表明,相对于G-CSF单独处理,在造血祖细胞动员方面用G-CSF和PGGβ-葡聚糖联合作用表现出协同效应.进一步研究表明,补体3和受体3在这方面都没起作用,用PGGβ-葡聚糖处理也没有诱导出促炎细胞因子分泌.但是,用PGGβ-葡聚糖处理的小鼠骨髓细胞中分泌出大量的基质金属蛋白酶-9（MMP-9）,并且PGGβ-葡聚糖诱导造血祖细胞活化作用在NMP-9缺陷小鼠中消失.此外,我们证实了用PGGβ-葡聚糖处理后,造血细胞和非造血细胞都对MMP-9分泌作出贡献.此外,被PGGβ-葡聚糖活化的造血祖细胞和被C-CSF活化的造血祖细胞在本体和细胞系分化能力方面来说有类似的植入水平.因此,PGGβ-葡聚糖是一种可以加强造血祖细胞作用的物质,并可以改善临床造血干细胞移植结果.干细胞 2008;26:1231～1240.