英语翻译本文主要研究了制备包封率在80%以上的盐酸阿霉素脂质体注射液,并具有一定的稳定性.该注射剂由阿霉素或盐酸阿霉素、

英语翻译
本文主要研究了制备包封率在80%以上的盐酸阿霉素脂质体注射液,并具有一定的稳定性.该注射剂由阿霉素或盐酸阿霉素、中性磷脂、负电荷磷脂、胆固醇、抗氧化剂、有机酸、碱、缓冲剂、注射剂用水,该制备工艺包括空白脂质体、均化脂质体、制备阿霉素或盐酸阿霉素脂质体及其混悬液、定容、除菌、分装、保存等步骤并对盐酸阿霉素脂质体进行包封率的测定.该注射剂稳定性好、包封率高、成本低、毒副作用少,该制备工艺简单易行.
本文研究利用pH梯度法制备阿霉素脂质体.通过纳米技术手段制得纳米囊后,通过调节囊内外离子浓度pH值,装载盐酸阿霉素,使得阿霉素从囊外进入纳米囊内,并且囊外阿霉素占总阿霉素的比例要低于20%

This paper mainly studies the preparation encapsulation efficiency in more than 80% of hydrochloric acid doxorubicin liposomes injection,and has certain stability.This injection by doxorubicin or hydrochloric acid doxorubicin,neutral lecithin phospholipid and negative and cholesterol,antioxidants,organic acid,alkali,slow granule,injection water,this preparation techniques including blank homogenization liposome,liposome,preparation doxorubicin or hydrochloric acid doxorubicin liposomes and its suspension liquid,the capacity,aseptic,repacking,steps and preservation of liposome of hydrochloric acid doxorubicin for the determination of encapsulation efficiency.This injection good stability,encapsulation efficiency high,low cost,fewer side effects,the preparation technology is simple.
This paper studies using pH gradient legal prepare liposomes adriamycin.Through the nano technology,made by adjusting after nanometer sac capsule inside and outside the concentration of the ions pH value,loading hydrochloric acid doxorubicin,make doxorubicin outside into the nano from sac,and sac within the capsule total adriamycin,the proportion of adriamycin lower than 20%
再问： 脂质体包封率的测定方法较多，其基本原理除了一些具有特性的（如荧光熄灯、特定的NMR信号等）的药物外，一般为首先分离游离药物，再测定被包封药物或游离药物，从而计算出包封率。本文还对包封率进行了测定，并对一些影响因素进行了验证。 最后一段了！谢谢！