英语翻译The amyloid hypothesis predicts that removal ofAb from t

英语翻译
The amyloid hypothesis predicts that removal ofAb from the brain,
or prevention of its accumulation,will ameliorate the Alzheimer
process.In transgenic animal models of Ab accumulation,both
passive and activeAb immunization can result in removal ofAb or
prevent its accumulation,resulting in functional benefits.Studies
of Ab immunization in humans with AD have provided “proof of
principle” thatAb accumulation can be reversed.However,there is
limited effect on some aspects of AD pathology,particularly tau
accumulation,and limited evidence of functional benefit.Current
concern with the Ab immunization approach is centered on an
unpredicted inflammatory complication that occurred in aminority
of AD patients,and therefore,immunization protocols aimed to
circumvent this problem are currently in clinical trials.The longterm
consequences of activation of the immune system on cognitive
function in AD may depend on the net balance of potentially
beneficial and harmful effects on the complex array of pathological
changes that are induced.Consequently,if it can be done safely,Ab
immunization at an earlier stage an preferably before irreversible
AD-related brain damage has occurred will be of interest.

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